Classes
DEA Class; Rx
Common Brand Names; Sanctura, Sanctura XR
- Anticholinergics, Genitourinary
Description
Oral non-specific antimuscarinic agent
Used for the treatment of overactive bladder (OAB) in adults
Dry mouth and constipation may occur; limited potential for drug-drug interactions
Indications
Indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urinary urgency, and urinary frequency, including neurogenic bladder.
Contraindications
Urinary/gastric retention
Uncontrolled narrow-angle glaucoma
Hypersensitivity
Adverse Effects
- Dry mouth (20.1%)
- Constipation (9.6%)
- Tachycardia (<2%)
- Headache (4.2%)
- Fatigue (1.9%)
- Rash (<2%)
- Dyspepsia (1-2%)
- Abdominal pain (1-3%)
- Abdominal distention (<2%)
- Constipation (9-10%)
- Dry eyes (1-2%)
- Dyspepsia (1-2%)
- Flatulence (1-2%)
- Urinary retention (<1%)
- Urinary tract infection (1-7%)
- Nasopharyngitis (3%)
- Nasal dryness (1%)
Warnings
Use caution in renal impairment, geriatric patients, moderate or severe hepatic dysfunction
Angioedema of the face, lips, tongue and/or larynx reported (including with 1st dose); if involvement of the tongue, hypopharynx, or larynx occurs promptly discontinue; promptly provide appropriate therapy and/or measures necessary to ensure a patent airway function
Administer with caution to patients with clinically significant bladder outflow obstruction or gastrointestinal obstructive disorders due to risk of urinary or gastric retention; use with caution in patients with conditions such as ulcerative colitis, intestinal atony, and myasthenia gravis
To administer, must carefully monitor patients with controlled narrow-angle glaucoma; benefits should outweigh risks
Somnolence reported; advise patients not to drive or operate heavy machinery until they know how therapy affects them
Pregnancy and Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use with caution
Maximum Dosage
60 mg/day PO.
60 mg/day PO.
Maximum dosage is not well-defined.
Maximum dosage is not well-defined.
How supplied
Trospium Chloride
tablet
20mg
capsule, extended release
60mg
