Rifabutin

DEA Class; Rx

Common Brand Names; Mycobutin

• Antitubercular Agents

Hypersensitivity to rifamycins

Concomitant live bacterial vaccines

• Discoloration of urine (30%)
• Neutropenia (25%)
• Leukopenia (17%)
• Rash (11%)
• Incr AST/ALT (7-9%)
• Thrombocytopenia (5%)
• Abdominal pain (4%)
• Diarrhea (3%)
• Eructation (3%)
• Headache (3%)
• Nausea/vomiting (3%)
• Anorexia (2%)
• Flatulence (2%)
• Anemia
• Myalgia

Monitor hematologic status

Eye pain, redness, loss of vision may indicate inflammatory ocular condition

Joint stiffness, swelling, tenderness or paresthesia may indicate arthralgias or myositis

May have brown-orange color of urine, feces, saliva, sputum, perspiration, tears, and skin

Severe Cutaneous Adverse Reactions

• Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) reported
• Closely monitor patients that develop a skin rash; discontinue therapy if lesions progress
• Specifically, for DRESS, a multi-system potential life-threatening SCAR, time to onset of first symptoms may be prolonged; DRESS is a clinical diagnosis, and its clinical presentation remains the basis for decision making; an early withdrawal of therapy is essential because of the syndrome’s mortality and visceral involvement (eg, liver, bone marrow or kidney)

Rifabutin crosses the placenta

No studies have examined if excreted in breast milk; however, women with HIV infection should not breastfeed

Rifabutin

capsule

• 150mg

oral solution

• 10mg/mL
• 20mg/mL