Polyethylene Glycol & Electrolytes

Osmotic laxative products may produce colonic mucosal aphthous ulcerations, including reports of more serious cases of ischemic colitis necessitating hospitalization

Concomitant use of stimulant laxatives may increase risk of ischemic colitis; not recommended; consider potential for mucosal aphthous ulceration as a result of bowel preparation, especially when evaluating colonoscopy results in patients with known or suspected inflammatory bowel disease

Generalized tonic-clonic seizures and/or loss of consciousness reported in patients with no prior history of seizures, which resolved with correction of fluid and electrolyte abnormalities; use caution in patients with history of seizures or who are at increased risk of seizures, including concomitant administration of medications that lower seizures threshold, patients withdrawing from alcohol or benzodiazepines, and patients with unknown or suspected hyponatremia or low serum osmolality

Use with caution and observe unconscious or semiconscious patients with impaired gag reflex or other swallowing abnormalities or those who are otherwise prone to regurgitation or aspiration during administration; observe these patients during administration, especially if it is administered via nasogastric tube

Avoid use in patients with bowel obstruction, megacolon, perforated bowel, ulcerative colitis, toxic colitis, gastric retention

Not indicated for children <2 years because of risk of hypoglycemia, dehydration, and hypokalemia

When using PEG as laxative, do not give for >1 week

Electrolyte imbalance reported with prolonged use