Classes
DEA Class; Rx
Common Brand Names; Dibenzyline
- Alpha Blockers, Antihypertensives
Description
Alpha-adrenergic antagonist; particularly effective in smooth muscle and exocrine glands
Useful in the treatment of sweating and hypertension associated with pheochromocytoma and for certain peripheral vasospastic conditions
Indications
Indicated For the treatment of excessive sweating and hypertension associated with pheochromocytoma.
For the treatment of peripheral vasospastic disorders (e.g., Raynaud’s phenomenon, acrocyanosis, or frostbite).
Contraindications
Hypersensitivity to phenoxybenzamine
Any conditions in which fall in BP is undesirable
Orthostatic hypotension
Adverse Effects
- Orthostatic hypotension
- Tachycardia
- Dizziness
- Drowsiness
- Fatigue
- Malaise
- Sedation
- Dry mouth
- Nausea
- Vomiting
- Inhibition of ejaculation
- Miosis
- Nasal congestion
Warnings
Cerebral or coronary arteriosclerosis, CHF, respiratory infection, renal impairment
Concomitant use of drugs that stimulate alpha/beta receptors (may increase hypotension/tachycardia)
May have carcinogenic potential
Use caution in the elderly (increased risk of adverse effects)
First dose effect may occur, causing a sudden and drastic fall in blood pressure after administering the first dose.
Hypotension/syncope may occur with first few doses or with increase in dose
Minimize by using small first dose at bedtime
Increase dose slowly
Pregnancy and Lactation
Pregnancy Category: C
Lactation: Not known if excreted into breast milk, discontinue drug or do not nurse
Maximum Dosage
Specific maximum dosage information is not available. Dosage should be based on efficacy and tolerance.
Specific maximum dosage information is not available. Dosage should be based on efficacy and tolerance.
Safety and efficacy have not been established.
Safety and efficacy have not been established, although doses up to 4 mg/kg/day PO have been used.
How supplied
Phenoxybenzamine hydrochloride
capsule
- 10mg
