Classes
DEA Class; Rx
Common Brand Names; Albenza
- Skeletal Muscle Relaxants
Description
Oral/parenteral centrally acting muscle relaxant; analog of diphenhydramine used primarily as adjunct therapy for acute, painful musculoskeletal conditions.
Indications
Indicated for muscle spasm and relief of discomfort associated with acute painful musculoskeletal conditions
Other Indications & Uses
Off-label: Leg cramps resistant to quinine, Parkinson’s disease
Contraindications
Hypersensitivity
Narrow-angle glaucoma
Pyloric/duodenal obstruction, BPH, stenosing peptic ulcers, cardiospasm (mega-esophagus), myasthenia gravis, obstructive uropathy, paralytic ileus, ulcerative colitis, toxic megacolon, achalasia
Adverse Effects
- Dry mouth
- Urinary retention
- Blurred vision, mydriasis
- Drowsiness
- Headache
- Weakness
- Increased IOP
- Palpitation
- Tachycardia
- GI disturbances
- CNS stimulation (restlessness, agitation, insomnia, mental confusion)
- Lightheadedness
- Dizziness
- Syncope
- Pruritus
- Urticarial rash
- Tremor
- Anaphylactic reactions
- Aplastic anemia
Warnings
Use caution in patients with diarrhea, partial obstructive uropathy, open-angle glaucoma, cardiovascular disease, hepatic/renal impairment, thyrotoxicosis, history of drug abuse or acute alcoholism
Some patients may experience transient episodes of light-headedness, dizziness or syncope; drug may impair ability of patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; ambulatory patients should be cautioned
May take with food to avoid stomach upset
Use with caution in patients with tachycardia, cardiac decompensation, coronary insufficiency, cardiac arrhythmias
Injectable form contains sulfites, & precipitates anaphylactic-type reactions in sensitive or asthmatic individuals
Safety of continuous long-term therapy not established; if orphenadrine is prescribed for prolonged use, periodic monitoring of blood, urine and liver function values is recommended
Pregnancy and Lactation
Pregnancy Category: C
Lactation: no data
Maximum Dosage
200 mg/day PO; 120 mg/day IV/IM.
200 mg/day PO; 120 mg/day IV/IM.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Orphenadrine citrate
injectable solution
- 30mg/mL
tablet, extended release
- 100mg
