Classes
DEA Class; Rx
Common Brand Names; Neo-Polycin, Neosporin Original Ointment, Triple Antibiotic Ointment
- Antibiotics, Ophthalmic Combos
- Antibacterials, Topical
Description
Neomycin; polymyxin B; bacitracin are available in topical and ophthalmic forms to treat infections of the eyes and skin. Neomycin and polymyxin B are primarily active against gram-negative, aerobic bacteria, while bacitracin is active against gram-positive bacteria.
Indications
Contraindications
Hypersensivity to neomycin, polymyxin B, zinc bacitracin
Glaucoma
Viral diseases of cornea and conjunctiva (epithelial herpes simplex keratitis, vaccinia, varicella)
Mycobacterial infection of eye & fungal diseases of ocular structures
Use in eyes or over large areas of body
Adverse Effects
Conjunctival edema
Rash
Allergic contact dermatitis
Itching
Failure to heal
Swelling
Irritation
Allergic contact dermatitis (60%)
Warnings
Contamination of container may occur, causing bacterial keratitis; avoid contamination of product
For external use only
Prolonged use may result in overgrowth of nonsusceptible organisms including fungi; if superinfection occurs, appropriate measures should be initiated
Bacterial resistance may develop; if purulent discharge, inflammation, or pain becomes aggravated, patient should discontinue use and consult a physician
Allergic cross-reactions may occur which could prevent use of any or all of the following antibiotics for treatment of future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin
Pregnancy and Lactation
Pregnancy Category: C
Lacation: Excretion in breast milk unknown; caution
Maximum Dosage
8 applications/day for up to 10 days for ophthalmic ointment; 3 applications/day for up to 7 days topically.
8 applications/day for up to 10 days for ophthalmic ointment; 3 applications/day for up to 7 days topically.
Safety and efficacy have not been established for ophthalmic ointment; 3 applications/day for up to 7 days topically.
>= 2 years: Safety and efficacy have not been established for ophthalmic ointment; 3 applications/day for up to 7 days topically.
< 2 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Neomycin/polymyxin B/bacitracin ophthalmic
ophthalmic ointment
- 400 units/3.5mg/10,000 units/g
Neomycin/polymyxin B/bacitracin topical
topical cream/ointment
- (3.5mg/5,000units/400units)/1gram
