Naproxen/Diphenhydramine

DEA Class;  Rx

Common Brand Names; Aleve PM

 Analgesics, Other Combos

Hypersensitivity

Naproxen

Absolute: Aspirin allergy; perioperative pain in setting of coronary artery bypass graft (CABG) surgery

Relative: Bleeding disorders, delayed esophageal transit, hepatic disease, peptic ulcer, renal impairment, stomatitis, late pregnancy (may cause premature closure of ductus arteriosus

Diphenhydramine

Coadministration with MAOIs

1-10%

Naproxen

• Abdominal pain
• GI bleeding
• Nausea
• Edema
• Fluid retention

Diphenhydramine

• Sedation
• Anticholinergic effects
• Xerostomia
• Blurred vision
• Palpitations

In case of overdose, get medical help or contact a Poison Control Center right away

Not recommmended for patients with likelihood of unrecognized CAD, severe renal impairment (CrCl <30 mL/min), or women who are breast feeding

Use NSAIDs with caution with underlying cardiovascular disease, active/history of peptic ulcer, inflammatory bowel disease, GI disease, bleeding disorder, renal/hepatic impairment, anemia, asthma, heart failure, edema, dehydration, HTN, or seizure disorder

Pregnancy

Use of NSAIDs can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment

Because of these risks, limit dose and duration of use between about 20 and 30 weeks of gestation, and avoid use at about 30 weeks of gestation and later in pregnancy

Lactation

Naproxen and diphenhydramine are excreted in human breast milk; effect on infant unknown; not recommended

naproxen/diphenhydramine

Tablet

• 220mg/25mg