Classes
DEA Class; Rx
Common Brand Names; Corzide
- Thiazide Combos;
- Beta-Blocker/Thiazide Diuretic Combos
Description
Beta-blocker and thiazide diuretic combination indicated for HTN; nadolol is a nonselective and hydrophilic beta-blocker lacking significant ISA or MSA, and is renally eliminated.
Indications
Indicated for the treatment of hypertension in patients who do not respond to monotherapy.
Contraindications
Anuria
Cardiogenic shock
Heart block 2°/3°
Hypersensitivity to either component or sulfonamides
Overt cardiac failure
Sinus bradycardia
Uncompensated cardiac failure
Asthma
Adverse Effects
No adverse effects specific to the combination have been observed; adverse effects limited to those previously reported with nadolol and bendroflumethiazide
Nadolol
- Abdominal discomfort
- Constipation
- Diarrhea
- CHF
- Nausea
- Cough
- Nasal congestion
- Drowsiness
- Insomnia
- Palpitaion
- Decreased sexual ability
- Bradycardia
- Dizziness
- Fatigue
- Hypotension
Bendroflumethiazide
- Hypotension
- Anorexia, epigastric distress
- Phototoxicity
- Hypercalcemia
- Hyperuricemia
- Hyperlipidemia
- Hypercholesterolemia
- Hypochloremia
- Hypokalemia (common)
- Hypomagnesemia
- Hyponatremia
- Glucose intolerance
Warnings
Anesthesia/surgery (myocardial depression); chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery, however the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures
Bronchospastic disease
Cerebrovascular insufficiency
CHF, beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe failure
DM, fluid or electrolyte imbalance, hyperuricemia or gout, hypotension, SLE
Liver disease
May aggravate digitalis toxicity
Peripheral vascular disease
Renal impairment
Risk of male sexual dysfunction
Sensitivity reactions may occur with or without history of allergy or asthma
May interfere with phenolsulfonphthalein test; may produce false negatives in phentolamine and tyramine tests
Avoid abrupt withdrawal
Pregnancy and Lactation
Pregnancy Category : C
Lactation: excreted in breast milk, use caution
Maximum Dosage
80 mg/day PO nadolol and 5 mg/day PO bendroflumethiazide.
80 mg/day PO nadolol and 5 mg/day PO bendroflumethiazide.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
nadolol/bendroflumethiazide
tablet
- 40mg/5mg
- 80mg/5mg
