Classes
DEA Class; Rx
Common Brand Names; Glyset
- Antidiabetics, Alpha-Glucosidase Inhibitors
Description
Oral alpha-glucosidase inhibitor; in contrast to acarbose, miglitol is systemically absorbed before acting in GI tract
Used for the treatment of type 2 diabetes mellitus
Agents in this class have only modest effects on A1C (i.e., mean 0.3% to 0.7% reduction)
Indications
Indicated for the treatment of type 2 diabetes mellitus as an adjunct to diet and exercise.
Contraindications
Hypersensitivity to miglitol
Diabetic ketoacidosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction
Disorders of GI digestion or absorption
Conditions that may deteriorate due to increased GI gas
Severe renal impairment
Adverse Effects
Flatulence (42%)
Diarrhea (29%)
Abdominal pain (12%)
Rash (4.3%)
Low serum iron
Warnings
Concurrent use with sulfonylureas may result in hypoglycemia; treat hypoglycemia with oral glucose, not sucrose
Pregnancy and Lactation
Pregnancy Category: B
Lactation: Enters slightly into breast milk; nor recommended
Maximum Dosage
300 mg/day PO.
300 mg/day PO.
Safety and efficacy have not been established.
Safety and efficacy not been established.
How supplied
Miglitol
tablet
- 25mg
- 50mg
- 100mg
