Methenamine/Hyoscyamine/Methylene Blue/Phenyl Salicylate/Sodium Phosphate Monobasic

DEA Class;  Rx

Common Brand Names; Uribel, Uticap, Utrona-C, Uretron D/S

Indicated for the treatment of symptoms of irritative voiding including for the relief of local urinary symptoms such as inflammation, hypermotility, and mild pain, which accompany lower urinary tract infection (UTI); also for the relief of urinary tract symptoms caused by diagnostic procedures.

Hypersensitivity to drugs or excipients

Hyoscyamine

• Dry skin

Methylene blue

• Urine and stool discoloration
• Limb pain
• Skin discoloration
• Feeling hot

Methenamine

• Pruritus
• Rash
• Dyspepsia
• Nausea
• Vomiting

Hyoscyamine

• Blurred vision
• Constipation
• Dysphagia
• Dysguesia

Methylene blue

• Headache
• Paresthesia
• Musculoskeletal pain

Use with caution in patients with a history of intolerance to salicylates or belladona alkaloids

Do not exceed dosage; discontinue use immediately if tachycardia, blurred vision, or tachycardia occurs

Delay in gastric emptying may complicate management of gastric ulcers

Hypersensitivity to any of the ingredients is possible; carefully consider risk and benefits in the presence of cardiac disease (especially cardiac arrhythmias, congestive heart failure, coronary heart disease, and mitral stenosis)

Use caution in patients with gastrointestinal tract obstructive disease, glaucoma, or myasthenia gravis; acute urinary retention may be precipitated in obstructive uropathy (eg, bladder neck obstruction due to prostatic hypertrophy)

Pregnancy

Reproduction studies not conducted with this drug combination; methenamine and hyoscyamine are known to cross the placenta; not known whether drug combination causes fetal harm when administered to a pregnant woman or if it can affect reproduction capacity; administer therapy to a pregnant woman only if clearly needed

Lactation

Problems in humans have not been documented; methenamine and traces of hyoscyamine are excreted in breast milk; administer therapy to a nursing mother with caution and only if clearly needed