Classes
DEA Class; Rx
Common Brand Names; Proctofoam HC, Analpram E, Analpram HC, Epifoam, ProCort, Pramosone, Pramosone E
- Anesthetics/Corticosteroid Combos;
- Corticosteroids, Gastrointestinal;
- Corticosteroids, Topical
Description
Combination of a glucocorticoid and local anesthetic
Used for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
Available in topical cream, lotion, ointment, and aerosol foams
Indications
Indicated for the treatment of corticosteroid-responsive dermatoses, including atopic dermatitis, localized vitiligo, eczema, phimosis, lichen planus, and localized bullous pemphigoid.
Contraindications
Hypersensitivity to any components of preparation
Adverse Effects
- Burning
- Itching
- Irritation
- Dryness
- Folliculitis
- Hypertrichosis
- Acneiform eruptions
- Hypopigmentation
- Perioral dermatitis
- Allergic contact dermatitis
- Maceration of the skin
- Secondary infection
- Skin atrophy
- Striae
- Miliaria
Warnings
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia and glucosuria
Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use and the addition of occlusive dressings
Evaluate susceptible patients periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests; If HPA axis suppression is noted, withdraw the drug, reduce frequency of application, or substitute a less potent steroid
Contact dermatitis may occur; discontinue use if irritation occurs and treat appropriately
Prolonged use may result in fungal or bacterial superinfection; discontinue if dermatological infection persists despite appropriate antimicrobial therapy
Topical corticosteroids may cause manifestations of Cushing’s syndrome, hyperglycemia, or glycosuria; absorption is increased by use of occlusive dressings, application to denuded skin, application to large surface, or prolonged use
Use caution in the elderly; use smallest possible effective dose for shortest duration
Do not insert any part of aerosol container directly into anus; discontinue if after 2-3 weeks there is no evidence of clinical or proctologic improvement or if condition worsens
Pregnancy and Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Maximum Dosage
No maximum dosage information is available.
No maximum dosage information is available.
No maximum dosage information is available.
>= 2 years: No maximum dosage information is available.
< 2 years: Safety and efficacy have not been established.
How supplied
Hydrocortisone/Pramoxine topical
hydrocortisone acetate/pramoxine hydrochloride
rectal aerosol foam
- 1%HC/1% pramoxine
cream
- 0.5%HC/1% pramoxine
- 1%HC/1% pramoxine
- 2.5%HC/1% pramoxine
lotion
- 1%HC/1% pramoxine
- 2.5%HC/1% pramoxine
