Classes
DEA Class; Rx
Common Brand Names; Horizant
- GABA Analogs
Description
Oral analog of GABA.
Used for restless legs syndrome, postherpetic and other neuralgias, and adjunctively for partial seizures; orphan drug for amyotrophic lateral sclerosis (ALS).
Monitor for emerging or worsening suicidal thoughts or actions and/or depression.
Indications
Indicated for moderate-to-severe primary restless legs syndrome
Indicated for management of postherpetic neuralgia (PHN)
Adverse Effects
- Somnolence/sedation (10-27%)
- Dizziness (13-30%)
- Headache (7-15%)
- Fatigue/asthenia (6-10%)
- Nausea (4-9%)
- Fatigue/asthenia (6-10%)
- Peripheral edema (6-7%)
- Insomnia (3-7%)
- Irritability (4%)
- Weight increase (2-5%)
- Blurred vision (2-5%)
- Xerostomia (3-4%)
- Flatulence (2-3%)
- Vertigo (1-3%)
- Peripheral edema (1-3%)
- Drunk/abnormal sensation (1-3%)
- Depression (1-3%)
- Decreased libido (1-2%)
Warnings
Safety and effectiveness in patients with epilepsy not studied
Pregnancy and Lactation
Pregnancy Category: C
Limited available data in pregnancy; use caution
Lactation: Unknown whether distributed in breast milk
Maximum Dosage
3600 mg/day PO (immediate-release products, e.g., Neurontin); 1800 mg/day PO (extended-release tablets; Gralise ONLY); 1200 mg/day PO (extended-release tablets; Horizant ONLY).
3600 mg/day PO (immediate-release products, e.g., Neurontin); 1800 mg/day PO (extended-release tablets; Gralise ONLY); 1200 mg/day PO (extended-release tablets; Horizant ONLY).
3600 mg/day PO (immediate-release products, e.g., Neurontin); safety and efficacy of extended-release gabapentin products have not been established.
3—12 years: 50 mg/kg/day PO immediate-release products has been suggested, higher dosages occasionally used in refractory patients. Safety and efficacy of extended-release gabapentin products have not been established.
< 3 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Gabapentin Enacarbil
tablet, extended-release
- 300mg
- 600mg
