Classes
DEA Class; Rx
Common Brand Names; Edecrin
- Diuretics, Loop
Description
Potent parenteral and oral loop diuretic; useful in patients who are unresponsive to other diuretics; greater risk of ototoxicity when compared to other loop diuretics.
Indications
Indicated for the treatment of peripheral edema, including idiopathic edema, lymphedema, or edema secondary to ascites, heart failure, or nephrotic syndrome.
For the acute treatment of hypercalcemia associated with neoplastic disease in combination with intravenous saline.
Contraindications
Hypersensitivity to ethacrynic acid
Anuria, severe, watery diarrhea
Use in infants
Adverse Effects
- Injection site reaction
- Hyperuricemia
- Gout
- Hypotension
- Hypokalemia
- Electrolyte abnormalities
- Hyperglycemia/hypoglycemia
- Hyperlipidemia
- Ototoxicity
- Tinnitus
- Photosensitivity
- Muscle cramps
- Dizziness
- Confusion
- Headache
- Nausea/vomiting
- Anorexia
- Dysphagia
- Diarrhea
- Pancreatitis
- Agranulocytosis
- Neutropenia
- Thrombocytopenia
- Hematuria
Warnings
Avoid concurrent use with lithium or furosemide
Diabetes mellitus, geriatrics, liver disease, renal impairment
Risk of fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, hypotension, metabolic alkalosis
Risk of ototoxicity (tinnitus, reversible/irreversible hearing impairment)
Discontinue use if severe, watery diarrhea occurs
Pregnancy and Lactation
Pregnancy Category: B
Lactation: excretion in milk unknown/not recommended
Maximum Dosage
400 mg/day PO or 100 mg/dose IV.
400 mg/day PO or 100 mg/dose IV.
3 mg/kg/day PO; safety and efficacy of IV administration has not been established but 1 mg/kg/dose IV has been used.
3 mg/kg/day PO; safety and efficacy of IV administration has not been established but 1 mg/kg/dose IV has been used.
Use is contraindicated.
How supplied
Ethacrynate sodium; Ethacrynic acid
powder for injection
- 50mg
tablet
- 25mg
