Classes
DEA Class; Rx
Common Brand Names; Velban
- Antineoplastics, Vinca Alkaloid
Description
Vinblastine is a member of the Vinca alkaloid antineoplastic agents; extracted from the periwinkle plant; similar to vincristine in action and structure, but the alkaloids significantly differ in toxicities and spectrum of activity; the dose-limiting toxicity of vinblastine is bone-marrow suppression.
Indications
Indicated for the treatment of breast cancer.
Contraindications
Hypersensitivity
Intrathecal (IT) administration
Active bacterial infection
Myelosuppression
Adverse Effects
- Anemia
- Leukopenia
- Myelosuppression
- Alopecia
- Peripheral neuropathy
- Hypertension
- Bronchospasm
- Nausea
- Vomiting
- Anorexia
- Diarrhea
- Constipation
- Paralytic ileus
- Jaw pain
- Aspermia
- Amenorrhea
Warnings
Bone marrow depression, neuropathy, neuromuscular disease may occur
Caution when administering neurotoxic agents, ototoxic agents concomitantly
Caution in pulmonary disease, liver impairment, intestinal obstruction, paralytic ileus
Potential for jaw/parotid pain, hoarseness & dysphagia due to cranial neuropathy
Vesicant
Previous radiation treatment or chemotherapy
Avoid pregnancy
Pregnancy and Lactation
Pregnancy Category: D
Lactation: not known if excreted in breast milk, do not nurse
Maximum Dosage
18.5 mg/m2 IV administered in weekly intervals.
18.5 mg/m2 IV administered in weekly intervals.
12.5 mg/m2/day IV administered weekly.
12.5 mg/m2/day IV administered weekly.
How supplied
Vinblastine sulfate
injectable solution
- 1mg/mL
powder for injection
- 10mg
