Vecuronium

DEA Class;  Rx

Common Brand Names; Norcuron

Indicated For muscular relaxation during non-emergent endotracheal intubation.

For muscular relaxation during non-emergent endotracheal intubation.

For neuromuscular blockade during mechanical ventilation in intensive care patients.

For neuromuscular blockade during surgery.

For muscular relaxation during rapid-sequence intubation (RSI)

For the prevention of shaking chills induced by therapeutic hypothermia after cardiac arrest.

Hypersensitivity

Lack of ventilatory support

Neuromuscular disease

• Skeletal muscle weakness or paralysis
• Respiratory insufficiency or apnea
• Hypersensitivity reactions associated with histamine release (e.g., bronchospasm, flushing, erythema, acute urticaria, hypotension, tachycardia)
• Itching
• Myositis ossificans (prolonged use)
• Acute quadriplegic myopathy syndrome (prolonged use)
• Less cardiovascular effects than pancuronium or atracurium

Additive/synergistic effects if administered with or following an opioid, sedative or anesthetic agent

Severe anaphylactic reactions to neuromuscular blocking agents have been reported; these reactions have, in some cases, been life threatening and fatal; because of the potential severity of these reactions, the necessary precautions, such as the immediate availability of appropriate emergency treatment, should be taken; neuromuscular cross-sensitivity with other nuromuscular blocking agents possible

Some patients may experience prolonged recovery (paralysis) of neuromuscular function

Adequate ventilatory support mandatory, may experience resistance with >25% TBSA burns, may experience increased sensitivity with electrolyte disorders (hyperMg, hypoK, hypoCa)

CAUTION: Hepatobiliary obstruction, renal dysfunction will significantly prolong duration of action

Pregnancy Category: C

Lactation: Not known if excreted in breast milk; effect on nursing infant not known; used during pregnancy only when clearly needed

Vecuronium Bromide

powder for injection

• 10mg
• 20mg