Classes
DEA Class; Rx
Common Brand Names; Trelstar Depot, Triptodur, Trelstar, Trelstar LA
- Antineoplastics, GNRH Agonist
Description
Agonist analog of gonadotropin-releasing hormone (GnRH)
Used for the palliative treatment of advanced prostate cancer and the treatment of central precocious puberty
Depression, including rare reports of suicidal ideation and attempt, has been reported with GnRH agonists in children treated for CPP
Indications
Indicated for Advanced Prostate Cancer
Trelstar: Due to different release characteristics, the dosage strengths are not additive and must be selected based upon the desired dosing schedule
Contraindications
Hypersensitivity
Pregnancy or women who may become pregnant
Adverse Effects
Trelstar
Hot flushes (82%)
Skeletal pain (17%)
Triptodur
Injection site pain (45%)
Nasopharyngitis (14%)
Headache (14%)
Injection site redness (14%)
Warnings
Risk of pituitary apoplexy (rare)
Hyperglycemia and an increased risk of developing diabetes have been reported in men receiving GnRH agonists
Cases of spinal cord compression, which may contribute to weakness or paralysis with or without fatal complications, have been reported with GnRH agonists
Reports of MI, sudden cardiac death, and stroke in men treated with GnRH agonists
Pregnancy and Lactation
Based on findings in animal studies and mechanism of action, therapy can cause fetal harm when administered to a pregnant woman
The safety and efficacy not established in females; there are no data on presence of drug in human milk, effects of drug on milk production
Maximum Dosage
Maximum dose is dependent on product strength; give no more than the 3.75 mg product IM every 4 weeks, the 11.25 mg product IM every 12 weeks, and the 22.5 mg product IM every 24 weeks.
Maximum dose is dependent on product strength; give no more than the 3.75 mg product IM every 4 weeks, the 11.25 mg product IM every 12 weeks, and the 22.5 mg product IM every 24 weeks.
22.5 mg IM every 24 weeks.
2 to 12 years: 22.5 mg IM every 24 weeks.
1 year: Safety and efficacy have not been established.
How supplied
Triptorelin pamoate
lyophilized powder for reconstitution (Trelstar)
- Reconstitution results in suspension for IM injection
- 3.75mg/vial
- 11.25mg/vial
- 22.5mg/vial
