Classes
DEA Class; OTC
Common Brand Names; Histex, Vanahist PD, Histex PD Drops, M-Hist PD, Vanaclear PD
- Antihistamines, 1st Generation
Description
First generation histamine-1 receptor antagonist
Indications
Indicated for temporary relief of rhinorrhea, sneezing, itchy nose, throat, or eyes owing to have fever or other upper respiratory allergies or allergic rhinitis
Contraindications
Patients taking sedatives or tranquilizers
Hypersensitivity; note that cross allergenicity may occur between chemically similar antihistamines
Adverse Effects
- Blurred vision
- Sedation
- Urinary retention
- Constipation
- Xerostomia
Warnings
May cause CNS depression, resulting in impaired physical or mental abilities; caution patients about performing tasks that require mental alertness (eg, driving, operating machinery)
Antihistamines may cause excitation in young children
Discontinue and contact physician if symptoms persist beyond 7 days or are accompanied by fever
Discontinue and contact physician if nervousness, dizziness, or sleeplessness occur
Do not exceed recommended dose
Discontinue therapy and ask doctor if new symptoms occur
Ask a healthcare professional before self-medication if experiencing breathing problems such as emphysema or chronic bronchitis, glaucoma, enlarged prostate (difficulty urinating)
Pregnancy and Lactation
Pregnancy
Limited data exist
Generally, antihistamines are considered low risk during pregnancy; however, exposure near birth of premature infants was associated with increased risk of retrolental fibroplasia
Lactation
Distributed in human breast milk; small, occasional doses are not expected to cause adverse effects in infant
Maximum Dosage
Histex: 2.5 mg (5 mL) PO q6hr
Vanahist PD or M-Hist PD: 2.5 mg (4 mL) PO q6hr
How supplied
Triprolidine
oral liquid
- 0.5mg/mL (Histex)
- 0.625mg/mL (Vanahist PD, M-Hist PD)
