Classes
DEA Class; Rx
Common Brand Names; Detrol, Detrol LA
- Anticholinergics, Genitourinary
Description
Oral competitive selective antimuscarinic agent; reduces incontinence episodes and urinary urgency
Used for treatment of overactive bladder (OAB) in adults; used as monotherapy or in combination with a beta-3 adrenoreceptor agonist if needed
Extensive study in elderly
Indications
Indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urinary urgency, and urinary frequency.
Contraindications
Urinary or gastric retention
Uncontrolled narrow-angle glaucoma
Hypersensitivity to drug or ingredients or to fesoterodine fumarate, which is metabolized to 5-hydroxymethyl tolterodine
Adverse Effects
- Dry mouth (40%)
- Blurred vision
- Constipation
- Dizziness
- Drowsiness
- Dyspepsia
- Headache
- Xerophthalmia
Warnings
Controlled narrow-angle glaucoma, hepatic, or renal impairment
Anaphylaxis and angioedema necessitating hospitalization and emergency treatment reported with first or subsequent doses; discontinue immediately if angioedema and hypotension, difficulty breathing, or airway obstruction develop
Anticholinergic central nervous system effects (eg, dizziness, somnolence) reported; patients should not drive or operate heavy machinery until they adjust to therapy
Use with caution in patients with myasthenia gravis, which is characterized by decreased cholinergic activity at neuromuscular junction
When coadministered with strong CYP3A4 inhibitors, tolterodine should be given at reduced dosage
Pregnancy and Lactation
There are no available data with use in pregnant women to inform drug-associated risks
There is no information on presence in human milk, effects on breastfed infant, or on milk production; based on limited data, tolterodine is excreted into milk in mice in low amounts
Maximum Dosage
4 mg/day PO.
4 mg/day PO.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Tolterodine tartrate
tablet, immediate release
- 1mg
- 2mg
capsule, extended release
- 2mg
- 4mg
