Classes
DEA Class; Rx
Common Brand Names; Skelid
- Calcium Metabolism Modifiers;
- Bisphosphonate Derivatives
Description
Bisphosphanate that inhibits bone resorption via actions on osteoclast activity, leading to an indirect increase in bone formation
Indications
Indicated for the treatment of Paget’s Disease
Contraindications
Hypersensitivity
Inability to stand or sit upright for at least 30 minutes
Abnormalities of the esophagus which delay emptying such as stricture or achalasia
Hypocalcemia
Adverse Effects
- Dizziness (4%)
- Edema (2.7%)
- Insomnia
- Flushing
- Hypertension
- Chest pain
- Back pain
- Musculoskeletal pain
- Diarrhea
- Dyspepsia
- Flushing
- Headache
- Nausea
- Rhinitis
- Sinusitis
- URI
Warnings
Risk of esophageal adverse effects, including esophagitis, esophageal ulceration/erosion, or esophageal bleeding with strictures or perforation
Following therapy, allow 3 months interval to assess response
Not recommended in severe renal failure (CrCl <30 mL/min)
Take with plain water only-NOT coffee, juice or mineral water; sit or stand upright for at least 30 minutes after administration
Risk of osteonecrosis of jaw
Food reduces bioavailability
Risk of severe bone, joint &/or muscle pain
Avoid concurrent multivalent cation-containing medicines or food
Pregnancy and Lactation
Pregnancy Category: C
Lactation: not known if crosses in to breast milk, use caution
Maximum Dosage
Paget’s Disease
400 mg PO qDay for 3 months
Renal Impairment
ClCr< 30 mL/min: Not recommended
Not removed by dialysis
How supplied
tiludronate (Discontinued)
tablet
- 200mg
