Ticlopidine

Discontinued

DEA Class; Discontinued

Common Brand Names; Ticlid

  • Antiplatelet Agents, Cardiovascular; 
  • Antiplatelet Agents, Hematologic

Oral platelet-aggregation inhibitor; associated with a risk of life-threatening blood dyscrasias; should be reserved for patients who are intolerant or allergic to aspirin therapy or who have failed aspirin therapy.

Indicated for arterial thromboembolism prophylaxis (e.g., stroke prophylaxis) to reduce the risk of sustaining an initial (fatal or nonfatal) thrombotic stroke after a transient ischemic attack (TIA) or to reduce the risk of recurrent thrombotic stroke in patients who have sustained a completed thrombotic stroke.

For subacute coronary thrombosis prophylaxis (i.e., abrupt closure) in combination with aspirin in recipients of a coronary artery stent following percutaneous coronary intervention (PCI).

For the treatment of acute myocardial infarction.
For the treatment of unstable angina as an alternative to aspirin.
For the treatment of intermittent claudication associated with peripheral vascular disease (PVD).

Documented hypersensitivity

Neutropenia, thrombocytopenia, hemostatic disorder or active bleeding (GI bleed, ICH), severe hepatic impairment, history of either thrombotic thrombocytopenic purpura (TTP) or aplastic anemia

Current use of other anticoagulant drugs

  • Diarrhea (12.5%)
  • Elevated alkaline phosphatase (7.6%)
  • Nausea (7%)
  • Dyspepsia (7%)
  • Rash (5%)
  • GI pain (3.7%)
  • Elevated AST/SGOT (3.1%)
  • Neutropenia (2.4%)
  • Purpura (2.2%)
  • Vomiting (1.9%)
  • Flatulence (1.5%)
  • Pruritus (1.3%)
  • Dizziness (1%)
  • Abnormal LFTs (1%)
  • Anorexia (1%)
  • Agranulocytosis
  • Aplastic anemia
  • Pancytopenia
  • TTP

Due to risk of adverse hematologic events, for stroke prevention use only in ASA-intolerant patients

Patients with lesions that have a propensity to bleed

Discontinue 10-14 days before elective major surgery in patients with bleeding diathesis

Increases serum chlesterol & triglyceride concentrations

Long-term use with concurrent aspirin not recommended

Pregnancy Category: B

Lactation: not known whether excreted in breast milk, discontinue drug or do not nurse

Adults

500 mg/day PO.

Elderly

500 mg/day PO.

Adolescents

Safety and efficacy have not been established.

Children

Safety and efficacy have not been established.

Ticlopidine hydrochloride

Discontinued

Drugs Generic
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