Classes
DEA Class; Rx
Common Brand Names; Suramin sodium
- Antiprotozoal Agents
Description
Trypanocidal activity; inhibits enzymes involved with the oxidation of reduced NADH
Indications
Indicated for
- Trypanosomiasis
- TB Gambiense
Treatment of hormone-refractory prostate cancer
Contraindications
Hypersensitivity
Adverse Effects
Vomiting
Urticaria
Paresthesia
Peripheral neuropathy
Kidney damage
Blood dyscrasias
Polyuria
Polydipsia
Pancytopenia
Shock
Optic atrophy
Warnings
Proteinuria and renal toxicity reported with use
Avoid use in renal or hepatic impairment
Pregnancy and Lactation
Pregnancy Category: no human studies conducted
Lactation: not known if excreted in breast milk
Maximum Dosage
Trypanosomiasis
100-200 mg (test dose) IV, then 1 g IV on days 1, 3, 7, 14, 21
TB Gambiense
10 mg/kg IV q5day to total of 12 injections
How supplied
Suramin
Powder for injectable solution
- 1g (reconstitute to100mg/mL)
