Stavudine

Brands

DEA Class; Rx

Common Brand Names; Zerit, d4T

  •  HIV, NRTIs

Nucleoside reverse transcriptase inhibitor (NRTI)
Used for treatment of HIV infection in combination with other antiretroviral agents
Associated with higher incidence of lactic acidosis with hepatic steatosis than other NRTIs

Indicated for the treatment of human immunodeficiency virus (HIV) infection in combination with other antiretroviral agents.

Hypersensitivity

Coadministration with didanosine

  • Headache
  • Chills/fever
  • Malaise
  • Insomnia
  • Anxiety
  • Depression
  • Pain
  • Rash
  • Nausea
  • Vomiting
  • Diarrhea
  • Pancreatitis
  • Abdominal pain
  • Peripheral neuropathy

Risk of potentially fatal lactic acidosis & severe hepatomegaly with steatosis, with use alone & especially with didanosine

Risk of potentially fatal pancreatitis when used with didanosine

Decrease dose in renal impairment

Severe motor weakness reported

Risk of immune reconstitution syndrome if used in combination w/ other antiretroviral drugs

Randomized controlled trials found lipoatrophy or lipodystrophy developed in a higher proportion of patients treated with stavudine compared to other nucleosides (tenofovir or abacavir)

There is a pregnancy exposure registry that monitors pregnancy outcomes in individuals exposed to drug during pregnancy

The Centers for Disease Control and Prevention recommend that HIV-infected mothers not breastfeed their infants to avoid risking postnatal transmission of HIV; based on limited data, the drug has been detected in human milk; no data are available regarding effects of stavudine on breastfed infant, or effects on milk production

Adults

Greater than to equal to 60 kg: 80 mg/day PO.
Less than 60 kg: 60 mg/day PO.

Geriatric

Greater than or equal to 60 kg: 80 mg/day PO.
Less than 60 kg: 60 mg/day PO.

Adolescents

Greater than or equal to 60 kg: 80 mg/day PO.
30 kg to less than 60 kg: 60 mg/day PO.
Less than 30 kg: 2 mg/kg/day PO.

Children

Greater than or equal to 60 kg: 80 mg/day PO.
30 kg to less than 60 kg: 60 mg/day PO.
Less than 30 kg: 2 mg/kg/day PO.

Infants

2 mg/kg/day PO oral solution.

Neonates

Greater than or equal to 14 days: 2 mg/kg/day PO oral solution.
Less than 14 days: 1 mg/kg/day PO oral solution.

Stavudine

capsule

  • 15mg
  • 20mg
  • 30mg
  • 40mg

powder for oral solution

  • 1mg/mL (200mL)
Drugs Generic
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