Rivastigmine

DEA Class;  Rx

Common Brand Names; Exelon, Exelon Patch

For the treatment of mild to moderate Parkinson’s disease dementia

For the treatment of Alzheimer’s disease.

For the treatment of severe Alzheimer’s disease.

For the treatment of Dementia with Lewy bodies

For the treatment of vascular dementia

Hypersensitivity to rivastigmine or carbamates

History of application site reaction with transdermal patch

Active GI bleeding

>10%

• Nausea (PO 47%; patch 21%)
• Vomiting (PO 31%; patch 6-19%)
• Dizziness (PO 21%; patch 2-7%)
• Diarrhea (PO 19%; patch 6-10%)
• Headache (PO 17%; patch 3-4%)
• Anorexia (PO 17%; patch 3-9%)
• Abdominal pain (PO 13%; patch 2-4%)

1-10%

• Decreased weight (3-8%)
• Insomnia (PO 9%; patch 1-4%)
• Anxiety (PO 5%; patch 3%)
• Asthenia (PO 6%; patch 2-3%)
• Vertigo (2%)
• Fatigue (2%)

Cardiac Disorders: Tachycardia

Hepatobiliary Disorders: Abnormal liver function tests, hepatitis

Nervous System Disorders: Seizure

Psychiatric Disorders: Aggression, nightmares

Skin and Subcutaneous Tissue Disorders: Allergic dermatitis, application site hypersensitivity (patch), blister, disseminated allergic dermatitis, Stevens-Johnson syndrome, urticarial

There are no adequate data on developmental risks associated with use of drug in pregnant women

There are no data on presence of drug in human milk, effects on breastfed infant, or on milk production