Classes
DEA Class; Rx
Common Brand Names; Visken
- Beta-Blockers, Intrinsic Sympathomimetic
Description
Oral beta-blocker and angiotensin II receptor blocker (ARB)
Used for the treatment of hOral, nonselective, beta-blocker; high degree of intrinsic sympathomimetic activity (ISA) (partial agonist activity); partial agonism is greater for beta-2 than beta-1 receptors, which may be associated with vasodilation; approved for HTN.ypertension
Can be used in patients not adequately controlled on valsartan 80 mg or nebivolol up to and including 10 mg or in patients already receiving 5 mg nebivolol and 80 mg valsartan
Indications
Indicated for the treatment of hypertension.
For treatment of chronic stable angina
Contraindications
Overt heart failure, asthma/COPD, cardiogenic shock, hypersensitivity, sinus bradycardia, 2nd-3rd degree heart block, cardiogenic shock, sick sinus syndrome without permanent pacemaker
Adverse Effects
- Insomnia (10%)
- Muscle pain (10%)
- Dizziness (9%)
- Fatigue (8%)
- Nervousness (7%)
- Elevated liver enzymes (7%)
- Joint pain (7%)
- Edema (6%)
- Vivid dreams (5%),
- Abdominal discomfort (4-5%)
- Nausea (4-5%)
- Muscle cramps (3%)
- Paresthesias (3%)
- Bradycardia (2%)
- Cold extremities (2%)
- Hypotension (2%)
- Palpitations (2%)
- Syncope (2%)
- Tachycardia (2%)
- Anxiety (2%)
- Lethargy (2%)
- Diarrhea (2%)
- Vomiting (2%)
- Impotence/reduced libido (1-2%)
Warnings
Use caution in anesthesia/surgery (myocardial depression), bronchospastic disease, cerebrovascular insufficiency, CHF, cardiomegaly, DM, hyperthyroidism/thyrotoxicosis, myasthenia gravis, liver disease, renal impairment, peripheral vascular disease, use in pheochromocytoma, IDDM, history of psychiatric disease, pre-existing sick sinus syndrome or similar cardiac conditions
Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery; the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures
Sudden discontinuation can exacerbate angina and lead to myocardial infarction
Less effective than thiazide diuretics in black and geriatric patients
Increased risk of stroke after surgery
Pregnancy and Lactation
Pregnancy Category: B
Lactation: do not nurse
Maximum Dosage
60 mg/day PO for hypertension; 40 mg/day PO for angina.
60 mg/day PO for hypertension; 40 mg/day PO for angina.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Pindolol
tablets
- 5mg
- 10mg
