Classes
DEA Class; Rx
Common Brand Names; Yodoxin
- Antiparasitic Agents
Description
Paromomycin (also known as aminosidine (injection), Gabbromicina) is an aminoglycoside antibiotic; spectrum of activity includes many of the protozoal species, gram negative aerobic bacteria (not Pseudomonas aeruginosa), Staphylococcus aureus and S. epidermidis. are resistant to paromomycin. Anaerobic bacteria, streptococci, and gram positive bacilli are relatively resistant.
Indications
Indicated for the adjunctive treatment of hepatic coma or hepatic encephalopathy (via suppression of intestinal bacterial growth).
Contraindications
Hypersensitivity, intestinal obstruction
Adverse Effects
- Diarrhea
- Abdominal cramps
- Nausea
- Vomiting
- Heartburn
- Headache
- Vertigo
- Exanthema
- Rash
- Pruritus
- Steatorrhea
- Secondary enterocolitis
- Eosinophilia
- Ototoxicity
Warnings
Prolonged treatment may result in fungal or bacterial superinfection
Caution in renal impairment or patients with ulcerative bowel lesions
Pregnancy and Lactation
Pregnancy Category: C
Lactation: does not enter breast milk
Maximum Dosage
Aminoglycoside dosing is highly variable and dependent on several factors. The FDA lists the maximum recommended therapeutic dose as 35 mg/kg/day; doses up to 45 mg/kg/day have been used.
Aminoglycoside dosing is highly variable and dependent on several factors. The FDA lists the maximum recommended therapeutic dose as 35 mg/kg/day; doses up to 45 mg/kg/day have been used.
Aminoglycoside dosing is highly variable and dependent on several factors. The FDA lists the maximum recommended therapeutic dose as 35 mg/kg/day; doses up to 45 mg/kg/day have been used.
Aminoglycoside dosing is highly variable and dependent on several factors. The FDA lists the maximum recommended therapeutic adult dose as 35 mg/kg/day; however, doses up to 45 mg/kg/day have been used in children and adults.
How supplied
Paromomycin sulfate
capsule
- 250mg
