Nystatin

DEA Class; Rx

Common Brand Names; Mycostatin, Nilstat, Nyamyc, Nystat Rx, Nystatin Systemic, Nystex

  • Antifungals, Other; 
  • Antifungals, Systemic
  • Vaginal

nystatin topical (Rx)

Brand and Other Names: Mycostatin topical, Pediaderm AF, PediDri, Nystop
  • Classes: Antifungals, Topical

Topical polyene antifungal antibiotic.
Used in the treatment of oropharyngeal, cutaneous, mucocutaneous, and vulvovaginal candidiasis; not useful for systemic fungal infections.
Adverse events tend to be minimal due to limited systemic absorption.

Indicated for the treatment of

  • Oropharyngeal Candidiasis
  • Intestinal Candidiasis
  • Invasive Fungal Infections (Orphan)
  • Liposomal nystatin: Treatment of invasive fungal infections
  • Vaginal Candidiasis
  • Mucocutaneous Infection

Hypersensitivity

  • Diarrhea
  • Nausea
  • Stomach pain
  • Vomiting
  • Contact dermatitis
  • Stevens-Johnson syndrome
  • Hypersensitivity reactions

Not for use in systemic mycoses

Discontinue therapy if irritation or sensitization observed during use

Pregnancy category: C

Lactation: Not known if excreted in breast milk; use caution

Adults

2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

Geriatric

2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

Adolescents

2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

Children

2.4 million units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

Infants

800,000 units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

Neonates

Neonates: 800,000 units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.
Premature Neonates: 400,000 units/day PO; maximum dosage information is not available for topical powder, cream, or ointment.

Nystatin

oral powder

  • 100,000units/g

oral suspension

  • 100,000units/mL

oral tablet

  • 500,000units

capsule

  • 500,000units
  • 1,000,000units

vaginal tablet

  • 100,000 units

cream/ointment/powder

  • 100,000 units/g

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