Classes
DEA Class; Rx
Common Brand Names; Nilandron
- Antineoplastics, Antiandrogen
Description
Oral antiandrogen; used for metastatic prostate CA; similar in action to bicalutamide and flutamide; differs from steroidal antiandrogens (e.g., finasteride) in that nilutamide is specific for the androgen receptor.
Indications
Indicated for the treatment of metastatic prostate cancer in combination with orchiectomy.
For the treatment of prostate cancer.
Contraindications
Hypersensitivity; severe hepatic, and/or respiratory impairment
Adverse Effects
- Hot flushes (28%)
- Testicular atrophy (16%)
- Altered adaptation to dark (13%)
- Dyspnea (11%)
- Heachache (undefined)
- Insomnia (undefined)
- Abdominal pain (10%)
- Nausea (10%)
- Constipation
- Diarrhea
- Aplastic anemia
- Leukopenia
- Alcohol intolerance
- Angina, heart failure
- HTN
- Syncope
- Dizziness
- Malaise
- Elevated LFTs
- Gynecomastia
- Impaired vision
- Interstitial pneumonitis
- UTI
Warnings
Hepatic Impairment
Hepatitis reported
Delay in vision adaptation to dark
Pregnancy and Lactation
Pregnancy Category: C
Lactation: N/A
Maximum Dosage
Adults
300 mg PO/day.
Elderly
300 mg PO/day.
Adolescents
Safety and efficacy have not been established.
Children
Safety and efficacy have not been established.
How supplied
Nilutamide
tablet
- 150mg
