Naftifine

DEA Class; Rx

Common Brand Names; Naftin

  • Antifungals, Topical

Topical allylamine antifungal
Indicated for the interdigital tinea pedis, tinea cruris, and tinea corporis
Similar efficacy and adverse events profiles to topical azole antifungals

Indications

  • 1% cream: Indicated for treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum
  • 1% gel: Indicated for treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton Tonsurans, and Epidermophyton floccosum
  • 2% cream or gel: Indicated for treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum

Hypersensitivity

Transient burning/stinging (5-6%)

Skin tenderness (0.5-3%)

Dryness

Erythema

Pruritus

Local irritation

Rash

Avoid use of occlusive dressings or wrappings

Keep the cream away from eyes, nose, mouth, & other mucous membranes

Reevaluate dx if no improvement after 4 wk

Discontinue treatment if irritation or sensitivity develops with use; direct patients to contact their physician if these conditions develop

Pregnancy: There are no available data in pregnant women to inform the drug-associated risk for major birth defects and miscarriage

Lactation: There is no information available on presence of drug in human milk, effects of drug on breastfed infant, or effects of drug on milk production

Adults

No maximum dosage information is available.

Geriatric

No maximum dosage information is available.

Adolescents

No maximum dosage information is available for the 2% gel or 2% cream; safety and efficacy have not been established for all other formulations.

Children

12 years: No maximum dosage information is available for the 2% gel or 2% cream; safety and efficacy have not been established for all other formulations.
2 to 11 years: No maximum dosage information is available for the 2% cream; safety and efficacy have not been established for all other formulations
< 2 years: Safety and efficacy have not been established.

Infants

Safety and efficacy have not been established.

Neonates

Safety and efficacy have not been established.

Naftifine hydrochloride

topical cream

  • 1%
  • 2%

topical gel

  • 1%
  • 2%

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