Classes
DEA Class; Rx
Common Brand Names; Asmanex Twisthaler, Asmanex HFA
- Corticosteroids, Inhalants
mometasone topical (Rx)
- Classes: Corticosteroids, Topical
mometasone sinus implant (Rx)
- Classes: Corticosteroids
Description
Synthetic corticosteroid; used topically, nasally and by inhalation
Topical products used for corticosteroid-responsive dermatoses; an oral inhalation is used for maintenance treatment of asthma
Nasal spray used for perennial/seasonal allergic rhinitis; sinus implants are used post-surgery to reduce inflammation and nasal polyp recurrence
Indications
Indicated for maintenance treatment of asthma as prophylactic therapy
Contraindications
Hypersensitivity
Immunosuppressed patients
Tuberculosis
Status asthmaticus or other acute asthma episode necessitating intensive measures
Known hypersensitivity to milk proteins or any other ingredients
Adverse Effects
- Headache (26%)
- Viral infection (14%)
- Pharyngitis (12%)
- Epistaxis (11%)
- Cough (7%)
- Upper respiratory tract infection (6%)
- Dysmenorrhea (5%)
Warnings
Respiratory tract tuberculosis, untreated fungal or bacterial infections, viral or parasitic infections, ocular herpes simplex
Nasal septum perforation, epistaxis, wheezing
Cataracts, glaucoma, increased intraocular pressure reported; consider referral to an ophthalmologist in patients who develop ocular symptoms or long term therapy
Risk of more serious or fatal course of chickenpox and measles in susceptible individuals; avoid use in unvaccinated or immunologically unexposed children or adults
Deaths from adrenal insufficiency have occurred after abrupt withdrawal of oral steroids; taper withdrawal gradually
May retard growth in children
Immunocompromised patients
Excessive use may suppress hypothalamic-pituitary-adrenal function
During periods of stress or severe status asthmaticus, patient may require supplementary systemic corticosteroids immediately; carry warning card to that effect
Long-term administration reduces bone mineral density
Pregnancy and Lactation
There are no randomized clinical studies in pregnant women
There are no available data on the presence in human milk, the effects on the breastfed child, or the effects on milk production
Maximum Dosage
In general, corticosteroid dosage must be individualized and is highly variable depending on the nature and severity of the disease, route and product of administration, and on patient age and response. For some products maximum dosage limits have not been specified.
400 mcg/day intranasally; 880 mcg/day oral inhalation via dry powder inhaler; 800 mcg/day oral inhalation via aerosol inhaler.
400 mcg/day intranasally; 880 mcg/day oral inhalation via dry powder inhaler; 800 mcg/day oral inhalation via aerosol inhaler.
Once daily application for cream, ointment, or lotion; 200 mcg/day intranasally; 880 mcg/day oral inhalation via dry powder inhaler; 800 mcg/day oral inhalation via aerosol inhaler.
12 years: Once daily application for cream, ointment, or lotion; 200 mcg/day intranasally; 880 mcg/day oral inhalation via dry powder inhaler; 800 mcg/day oral inhalation via aerosol inhaler.
5 to 11 years: Once daily application for cream or ointment; 100 mcg/day intranasally; 110 mcg/day oral inhalation via dry powder inhaler; 200 mcg/day oral inhalation via aerosol inhaler.
4 years: Once daily application for cream or ointment; 100 mcg/day intranasally; 110 mcg/day oral inhalation via dry powder inhaler; safety and efficacy have not been established for aerosol inhaler.
2 to 3 years: Once daily application for cream or ointment; 100 mcg/day intranasally. Safety and efficacy have not been established for inhaler products or lotion.
Younger than 2 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
