Classes
DEA Class; Rx
Common Brand Names; Novantrone
- Antineoplastics, Anthracenedione;
- Multiple Sclerosis Treatments
Description
Anthracenedione; structurally similar to the anthracyclines; causes less cardiotoxicity than anthracylines; not a vesicant; used in hematologic malignancies and prostate cancer; also effective in relapsing-remitting and secondary progressive MS.
Indications
Indicated for the treatment of acute myelogenous leukemia (AML).
For the palliative treatment of severe pain related to advanced hormone-refractory prostate cancer in combination with corticosteroids.
For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis to reduce neurologic disability and/or frequency of clinical relapses.
Contraindications
Hypersensitivity
Adverse Effects
- Nausea (55%)
- Upper respiratory infection (51%)
- Alopecia (38%
- Urinary tract infection (29%)
- Amenorrhea (28%)
- Diarrhea (25%)
- Stomatitis (15%)
- Constipation (14%)
- Headache (6%)
- Back pain (6%)
Warnings
Not indicated for primary progressive MS
Risk of cardiotoxicity & secondary AML
Avoid pregnancy
If extravasation occurs, stop immediately & restart in another vein
Hepatic impairment
Pregnancy and Lactation
Pregnancy Category: D
Lactation: excreted in breast milk, do not nurse
Maximum Dosage
The maximum cumulative lifetime dose of mitoxantrone is 140 mg/m2 IV.
How supplied
Mitoxantrone
injectable solution
- 2mg/mL
