Miglitol

DEA Class; Rx

Common Brand Names; Glyset

  • Antidiabetics, Alpha-Glucosidase Inhibitors

Oral alpha-glucosidase inhibitor; in contrast to acarbose, miglitol is systemically absorbed before acting in GI tract
Used for the treatment of type 2 diabetes mellitus
Agents in this class have only modest effects on A1C (i.e., mean 0.3% to 0.7% reduction)

Indicated for the treatment of type 2 diabetes mellitus as an adjunct to diet and exercise.

Hypersensitivity to miglitol

Diabetic ketoacidosis, inflammatory bowel disease, colonic ulceration, partial intestinal obstruction

Disorders of GI digestion or absorption

Conditions that may deteriorate due to increased GI gas

Severe renal impairment

Flatulence (42%)

Diarrhea (29%)

Abdominal pain (12%)

Rash (4.3%)

Low serum iron

Concurrent use with sulfonylureas may result in hypoglycemia; treat hypoglycemia with oral glucose, not sucrose

Pregnancy Category: B

Lactation: Enters slightly into breast milk; nor recommended

Adults

300 mg/day PO.

Geriatric

300 mg/day PO.

Adolescents

Safety and efficacy have not been established.

Children

Safety and efficacy not been established.

Miglitol

tablet

  • 25mg
  • 50mg
  • 100mg

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