Classes
DEA Class; Rx
Common Brand Names;
- Antianxiety Agents;
- Anxiolytics, Nonbenzodiazepines
Description
Carbamate derivative; inhibitory effects in thalamus, limbic system; may inhibit multineural spinal reflexes
Mild sedative, anticonvulsant, muscular relaxant effects
Indications
Indicated for the treatment of anxiety, Preoperative Sedation.
Contraindications
Hypersensitivity, allergy to related drugs (eg, carisoprodol)
History of porphyria
Adverse Effects
Common
Abnormal ECG, palpitations, tachyarrhythmia
Asthenia, ataxia, dizziness, EEG abnormality, euphoria, fast, excitement, paradoxical, headache, paresthesia, slurred speech, somnolence, vertigo
Hives, maculopapular eruption, erythematous
Diarrhea, nausea, vomiting
Disorder of accommodation (ocular)
Serious
Cardiac dysrhythmia, hypotension crisis, syncope
Bullous dermatosis (rare), Stevens-Johnson syndrome (rare)
Agranulocytosis, aplastic anemia, leukopenia
Anaphylaxis (rare)
Warnings
Hypersensitivity may occur
May impair physical or mental abilities due to CNS depression
Secreted into breast milk; avoid during breastfeeding
Caution in patientw with depression or suicidal tendencies
Caution in hepatic/renal impairment or seizure disorder
Pregnancy and Lactation
Pregnancy Category: D
Lactation: secreted into breast milk at 2-4x plasma concentration; avoid
Maximum Dosage
Anxiety
1200-1600 mg/day PO divided q6-8hr; not to exceed 2.4 g/day
Preoperative Sedation
400 mg PO before the procedure
Pediatric
Anxiety
<6 years old: Not recommended6-12 years old: 100-200 mg PO q8-12hr
>12 years old: 1200-1600 mg/day PO divided q8-12hr; not to exceed 2.4 g/day
Preoperative Sedation
200 mg PO prior to procedure
How supplied
Meprobamate
tablet: Schedule IV
- 200mg
- 400mg
