Mebendazole

Brands

DEA Class; Rx

Common Brand Names; Emverm, Vermox

  • Anthelmintics

Oral, broad-spectrum, synthetic anthelmintic agent
Used for infections caused by GI nematodes, such as roundworms, whipworms, pinworms, and hookworms
Along with pyrantel pamoate, drug of choice for these infections

Indicated for the treatment of trichuriasis (whipworm infection) or ascariasis (roundworm infection) or mixed infections with these parasites.

For the treatment of enterobiasis (pinworm infection).
For the treatment of hookworm infection.
For the treatment of cystic echinococcosis (hydatid cyst disease) and alveolar echinococcosis.
For the treatment of capillariasis.
For the treatment of toxocariasis (visceral larva migrans).
For the treatment of trichinosis.
 
 

Hypersensitivity

  • Angioedema
  • Fever
  • Dizziness
  • Headache
  • Hematuria
  • Leukopenia
  • Seizures
  • Drowsiness
  • Decreased hemoglobin
  • Rash
  • Itching
  • Agranulocytosis
  • Alopecia (with high doses)
  • Abdominal pain
  • Diarrhea
  • Nausea
  • Toxic epidermal necrolysis
  • May increase AST, ALT, and GGT (hepatitis)
  • Stevens-Johnson syndrome
  • Vomiting
  • Neutropenia (sore throat, unusual fatigue)
  • Toxic epidermal necrolysis
  • Unusual weakness
  • Glomerulonephritis

Neutropenia and agranulocytosis reported with high doses

Not effective for hydatid disease

Systemic exposure may increase with hepatic impairment

Pregnancy category: C

Lactation: Excretion in breast milk unknown; use caution

Adults

500 mg/day PO for single dose regimen; 200 mg/day PO is FDA-approved maximum for 3-day regimen; a dose of 40 mg/kg PO has been used off-label for hydatid cyst disease.

Geriatric

500 mg/day PO for single dose regimen; 200 mg/day PO is FDA-approved maximum for 3-day regimen; a dose of 40 mg/kg PO has been used off-label for hydatid cyst disease.

Adolescents

500 mg/day PO for single dose regimen; 200 mg/day PO is FDA-approved maximum for 3-day regimen; a dose of 40 mg/kg PO has been used off-label for hydatid cyst disease.

Children

2 to 12 years: 500 mg/day PO for single dose regimen; 200 mg/day PO is FDA-approved maximum for 3-day regimen; a dose of 40 mg/kg PO has been used off-label for hydatid cyst disease.
1 to 2 years: 500 mg/day PO for single dose regimen; safety and efficacy have not been established for 3-day regimen.

Infants

Safety and efficacy have not been established.

Neonates

Safety and efficacy have not been established.

Mebendazole 

tablet, chewable

  • 100mg (Emverm)
  • 500mg (Vermox)
Drugs Generic
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