Hydroquinone

DEA Class; Rx

Common Brand Names;

• Depigmenting Agents

Elicits reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3, 4-dihydroxyphenylalanine (DOPA); also suppresses other melanocyte metabolic processes; sun exposure reverses effect and cause repigmentation

Physicians may prescribe hydroquinone products through 503A and 503B compounding facilities

Hypersensitivity

Sunburn

Use as depilatory drug

• Mild skin irritation and sensitization (burning, stinging)
• Dermatitis
• Dryness
• Erythema
• Inflammatory reaction

May contain sulfites that may cause allergic-type reactions

May cause skin rashes, facial swelling, and ochronosis

Avoid unnecessary exposure to sunlight

Limit application to areas no larger than arms, hands, face, and neck

Do not apply near eyes or mucous membranes, to cut, abraded, or sunburned skin, after shaving or using a depilatory agent; or over miliaria rubra (prickly heat)

Individuals with sensitive skin may experience temporary burning/stinging sensation

Pregnancy

Unknown extent of systemic absorption

Lactation

Unknown if distributed in breast milk; use caution

Hydroquinone