Flutamide

DEA Class; Rx

Common Brand Names; 

Nonsteroidal antiandrogen; most effective in prostate cancer when used simultaneously with LHRH agonists; not effective in treating other hormonally dependent diseases such as breast cancer.

Hypersensitivity, severe hepatic disease

• Hot flashes (61%)
• Decreased libido (36%)
• Impotence (31%)
• Diarrhea (12%)
• Nausea/vomiting (11%)
• Gynecomastia (9%)
• Anorexia (4%)
• Edema (4%)
• Leukopenia (3%)
• Rash (3%)
• Hemolytic anemia, methemoglobinemia
• Increased AST, ALT, bilirubin, BUN

Risk of severe liver injury

Potential for aniline toxicity (methemoglobinemia, hemolytic anemia etc); specially monitor patients sensitive to aniline toxicity

Risk for cardiovascular disease may increase with androgen deprivation

Pregnancy Category: D

Lactation: Excretion in milk unknown; not recommended