Diethylcarbamazine

DEA Class; Rx

Common Brand Names; Hetrazan

• Anthelmintics

Indicated for

• Filarial Diseases
• Loa Loa
• M. Streptocerca
• Tropical Pulmonary Eosinophilia 
• Larva Migrans, Visceral

• Encepholopathy (rare)
• Fever
• GI disturbances

Pregnancy Category: X

Lactation: not known if excreted in breast milk

Filarial Diseases

IND protocol from CDC available for treatment of certain filarial diseases, including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori

Day 1: 50 mg PO PC

Day 2: 50 mg PO TID

Day 3: 100 mg PO TID

Day 4-14: 6 mg/kg/day PO divided TID

Loa Loa

Day 1: 50 mg PO PC

Day 2: 50 mg PO TID

Day 3: 100 mg PO TID

Day 4-21: 9 mg/kg/day PO divided TID

M. Streptocerca

6 mg/kg PO qDay x14 days  

Tropical Pulmonary Eosinophilia

IND protocol from CDC available for treatment of tropical pulmonary eosinophilia

Pulmonary eosinophilia, tropical: 6 mg/kg/day divided TID x14 days  

Larva Migrans, Visceral

6 mg/kg/day PO divided TID x7-10 days 

Not commercially available in the U.S.

Diethylcarbamazine

tablet

• 100mg