Classes
DEA Class; Rx
Common Brand Names; Cerubidine
- Antineoplastics, Anthracycline
Description
Anthracycline chemotherapy agent
Used in combination with other anticancer drugs in patients with acute leukemias
Cardiotoxicity and myelosuppression have been reported
Indications
Indicated for the treatment of acute nonlymphocytic leukemia including acute myelogenous leukemia (AML).
Contraindications
Hypersensitivity
Active infection
IM or SC administration (vesicant)
Patients who have received max cumulative dose of daunorubicin or doxorubicin
Patients with preexisting myelosuppression from other drug treatments
Adverse Effects
- Nausea
- Vomiting
- Arrhythmias
- Discoloration of urine
- Alopecia
- Injection site skin flare
- Hyperuricemia
- GI ulceration
- Diarrhea
- Arrhythmia
- Cardiomyopathy
- Bilirubin increased
- Pruritus
- Urticaria
Warnings
Risk of severe cardiotoxicity (including CHF) & myelosuppression
Caution in hepatic/renal impairment
Children may be more sensitive to cardiotoxic effects than adults
Avoid pregnancy
Secondary leukemias reported when used in combination with radiation or chemotherapy
Pregnancy and Lactation
Pregnancy Category: D
Lactation: excretion in milk unknown/not recommended
Maximum Dosage
45 mg/m2 IV, although doses up to 90 mg/m2 IV have been used off-label; maximum cumulative anthracycline dose is 550 mg/m2 (or 400 mg/m2 in patients who have received radiation therapy involving the heart area).
45 mg/m2 IV, although doses up to 90 mg/m2 IV have been used off-label; maximum cumulative lifetime anthracycline dose is 550 mg/m2 (or 400 mg/m2 in patients who have received radiation therapy involving the heart area).
25 mg/m2 IV weekly; maximum cumulative dose is 300 mg/m2 IV.
2 years or older: 25 mg/m2 (or 1 mg/kg in children with a body surface area less than 0.5 m2); maximum cumulative dose is 300 mg/m2 IV.Less than 2 years: 1 mg/kg IV weekly label; maximum cumulative dose is 10 mg/kg.
1 mg/kg IV weekly label; maximum cumulative dose is 10 mg/kg.
How supplied
Daunorubicin hydrochloride
injectable solution
- 5mg/mL
powder for injection
- 20mg
