Classes
DEA Class; Rx
Common Brand Names; Capastat
- Antitubercular Agents
Description
Bacteriostatic or bactericidal
Inhibits cell wall synthesis
Indications
Indicated for treatment of Tuberculosis
Contraindications
Hypersensitivity
Alcohol use
Renal dysfunction, severe
History of seizure disorder, mental depression, severe anxiety or psychosis
Adverse Effects
- Confusion
- Restlessness
- Drowsiness
- Vertigo
- Cardiac arrhythmia
- Folate deficiency
- Hyperreflexia
- Dysarthria
- Dizziness
- Headache
- Coma
- Liver enzymes increased
- Somnolence
- Paresis
- Seizure
- Heart failure
Warnings
Caution in patients with history of alcoholism (may increase seizures), anemia, impaired hepatic/renal function
CNS toxicity (depression, seizures, psychosis) may occur
Prolonged use may result in fungal or bacterial superinfection (C. difficile-associated diarrhea)
Pregnancy and Lactation
Pregnancy Category: C
Lactation: enters breast milk; safe
Maximum Dosage
Active Tuberculosis
Initial: 250 mg PO q12hr for 14 days THEN
500 mg -1 g/day divided q12hr for 18-24 months; not to exceed 1 g/day
Monitor blood levels
UTI
Initial: 250 mg PO q12hr for first 14 days
Maintenance: 500 mg -1 g/day in divided doses; not to exceed 1 g/day
Monitor blood levels
Gaucher’s Disease (Orphan)
Orphan indication sponsor
Lev, Meir M.D.; The City College, City University Of NY Medical Sc, Convent Avenue at 138 Street; New York, NY 10031
How supplied
Cycloserine
capsule
- 250mg
