Classes
DEA Class; OTC
Common Brand Names; Marezine, Bonine for Kids, Cyclivert
- Antiemetics, Antihistamine
Description
Cyclizine is a piperazine derivative that has antiemetic, anticholinergic, and antihistaminic properties; reduces the sensitivity of the labyrinthine apparatus and has central actions on the chemoreceptor trigger zone
Indications
Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness
Contraindications
Hypersensitivity
Do not use in patients with asthma, glaucoma, emphysema, chronic pulmonary disease, shortness of breath, difficulty in breathing or difficulty in urination due to enlargement of the prostate gland unless directed by a doctor
Cyclizine should not be used concurrently with sedatives, tranquilizers, or anticholinergic medications
Adverse Effects
- Drowsiness
- Xerostomia
- Headache
- Dermatitis
- Nausea
- Urinary retention
- Diplopia
- Polyuria
Warnings
May have hypotensive effects, which may be confusing or dangerous in postoperative patients
May produce drowsiness; caution while driving or performing other tasks requiring alertness
Pregnancy and Lactation
Pregnancy Category: B
Lactation: unknown
Maximum Dosage
50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day
50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day
6-12 years: 25 mg PO up to 3 times/day; not to exceed 75 mg/day
>12 years: 50 mg PO taken 30 minutes before departure, may repeat in 4-6 hr if needed, up to 200 mg/day
How supplied
Cyclizine
tablet
- 25mg
- 50mg
