Classes
DEA Class; OTC, Rx
Common Brand Names; Dailyhist-1, Tavist Allergy
- Antihistamines, 1st Generation
Description
Oral sedating first-generation antihistamine with a longer duration of action (12 hours)
Used to temporarily reduce symptoms of the common cold, seasonal allergies, and other respiratory allergies such as rhinorrhea, itchy, watery eyes, sneezing, and nasal and throat pruritus
Indications
Indicated for
- Allergic Rhinitis
- Urticaria
- Angioedema
Other Indications & Uses
Perennial & seasonal allergic & vasomotor rhinitis, relief of symptoms from colds, urticaria, angioedema, anaphylactic reactions, pruritus, allergic conjunctivitis
Contraindications
Documented hypersensitivity
Lower respiratory disease, eg, asthma (controversial)
Preemies & neonates
Nursing women
Adverse Effects
- CNS depression
- Drowsiness
- Sedation ranging from mild drowsiness to deep sleep (most frequent)
- Dizziness
- Lassitude
- Disturbed coordination
- Muscular weakness
- Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common
- Epigastric distress
- Anorexia
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare
- Eczema, pruritus, inflammation, papular rash, erythema on exposed skin may occur with topical formulation
- Tachycardia, palpitation ECG changes (eg, widened QRS) Arrhythmias (eg, extrasystole, heart block)
- Hypotension
- Hypertension
- Dizziness, sedation, and hypotension may occur in geriatric patients
- Dryness of mouth, nose, and throat
- Dysuria
- Urinary retention
- Impotence
- Vertigo
- Visual disturbances
- Blurred vision
Warnings
Caution in narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction
Pregnancy and Lactation
Pregnancy Category: B
Lactation: enters breast milk/not recommended
Maximum Dosage
8.04 mg/day PO clemastine fumarate; 6 mg/day PO clemastine base.
8.04 mg/day PO clemastine fumarate; 6 mg/day PO clemastine base. The elderly are more sensitive to anticholinergic effects.
8.04 mg/day PO clemastine fumarate; 6 mg/day PO clemastine base.
12 years: 8.04 mg/day PO clemastine fumarate; 6 mg/day PO clemastine base.
6 to 11 years: 4.02 mg/day PO clemastine fumarate; 3 mg/day PO clemastine base.
Less than 6 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
Use is contraindicated.
How supplied
Clemastine fumarate
tablet
- 1.34mg
- 2.68mg
syrup
- 0.67mg/5mL
