Classes
DEA Class; Rx
Common Brand Names; Tagamet HB
- Histamine H2 Antagonists
Description
Oral/parenteral histamine type 2-receptor antagonist.
Used for gastrointestinal disorders such as peptic ulcer and gastroesophageal reflux disease (GERD)
Exhibits many clinically significant drug interactions due to inhibition of CYP450 enzymes.
Indications
Indicated for
- Benign Gastric Ulcer
- Duodenal Ulcer
- Erosive Gastroesophageal Reflux Disease
- Heartburn
Other Indications & Uses
PUD (treatment, maintenance), gastric ulcer treatment, GI bleeding prevention in critically ill patients, hypersecretory conditions (e.g., Zollinger-Ellison)
Contraindications
Hypersensitivity to cimetidine or other H2 receptor antagonists
Adverse Effects
- Headache (2.1%)
- Dizziness (1%)
- Somnolence (1%)
- Gynecomastia (0.3-4%)
- Confusion (elderly)
- Impotence
- Diarrhea
- Nausea
- Vomiting
Warnings
Antiandrogen: may cause feminization & sexual dysfunction in males
If patient taking a prescription drug, the patient should ask a doctor or a pharmacist whether cimetidine can be taken concomitantly with it
Pregnancy and Lactation
Pregnancy Category: B
Lactation: enters breast milk/not recommended
Maximum Dosage
1200 mg/day PO for most indications, 1600 mg/day PO for GERD. Up to 2400 mg/day PO for pathologic hypersecretory conditions.
1200 mg/day PO for most indications, 1600 mg/day PO for GERD. Up to 2400 mg/day PO for pathologic hypersecretory conditions.
< 16 years: 40 mg/kg/day PO for most indications; data are limited.
>= 16 years: 1200 mg/day PO or IV for most indications. 1600 mg/day PO for GERD. Up to 2400 mg/day PO for pathologic hypersecretory conditions.
40 mg/kg/day PO or IV for most indications; data are limited.
40 mg/kg/day PO or IV; data are limited.
20 mg/kg/day PO or IV; data are limited.
How supplied
Cimetidine
injectable solution
- 150mg/mL
oral solution
- 300mg/5mL
tablet
- 200mg
- 300mg
- 400mg (Rx)
- 600mg (Rx)
- 800mg (Rx)
