Classes
DEA Class; Rx
Common Brand Names; Children’s Robitussin Cough & Cold Long-Acting, St. Joseph Cough & Cold
- Cough/Cold, Non-narcotic Combos;
- Antihistamine/Antitussive Combos
Description
Oral sedating antihistamine and non-opioid antitussive combination
Used to relieve symptoms associated with the common cold or allergies including rhinorrhea, sneezing, and cough in adults and pediatric patients 6 years and older
These products may be abused due to dextromethorphan content and are known by the slang term “Triple C”
Indications
Indicated for the relief of cough, rhinorrhea, and sneezing due to the common cold.
Contraindications
Hypersensitivity
Within 2 wk of taking a monoamine oxidase (MAO) inhibitor
Sedation of children
Adverse Effects
- Sedation ranging from mild drowsiness to deep sleep
- CNS depression
- Excitability may occur in children
- Dizziness
- Impaired coordination
- Muscular weakness
- Anorexia
- Nausea
- Vomiting
- Urinary retention
- Blurred vision
- Xerostomia
- Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitations, seizures reported infrequently
Warnings
Caution in children younger than 6 years
Benign prostatic hypertrophy
Glaucoma
Caution in productive cough (do not suppress expectoration of phlegm)
Chronic respiratory conditions (eg, asthma, COPD)
Alcohol consumption or other CNS depressants may increase risk for drowsiness
May impair ability to safely drive vehicle or operate machinery
Pregnancy and Lactation
Pregnancy Category: C
Lactation: Unknown whether distributed in breast milk, caution advised
Maximum Dosage
Do not exceed recommended dosage limits for the specific product prescribed; the following are general guidelines:
Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
12 years: Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
6 to 11 years: Chlorpheniramine 12 mg/day PO; dextromethorphan 60 mg/day PO.
Less than 6 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Chlorpheniramine/dextromethorphan
chlorpheniramine maleate/dextromethorphan hydrobromide
softchew tablet
- 1mg/5mg
oral syrup
- (1mg/7.5mg)/5mL
- (2mg/15mg)/5mL
tablet
- 4mg/30mg
