Classes
DEA Class; Rx
Common Brand Names; Simulect
- Immunouppressants;
- Monoclonal Antibodies
Description
Immunosuppressant; chimeric (murine/human) monoclonal antibody (IgG); binds to and blocks the interleukin-2 receptor alpha chain (CD25); has not been associated with an increased risk of lymphoma or other malignancies.
Indications
Indicated for acute kidney transplant rejection prophylaxis when used as part of an immunosuppressive regimen that includes cyclosporine and corticosteroids.
For acute liver transplant rejection prophylaxis when used as part of an immunosuppressive regimen that includes cyclosporine and corticosteroids.
Contraindications
Hypersensitivity
Warnings
Development of human antimurine antibodies reported for murine products
Risk of developing lymphoproliferative disorders may increase with immunosuppressive therapy
Immunosuppressive therapy may increase risk of opportunistic infection
Pregnancy and Lactation
Pregnancy Category: B
Lactation: Unknown whether excreted in milk; because of the potential for adverse reactions, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Maximum Dosage
20 mg IV as a single dose.
20 mg IV as a single dose.
>= 35 kg: 20 mg IV as a single dose.
< 35 kg: 10 mg IV as a single dose.
>= 35 kg: 20 mg IV as a single dose.
< 35 kg: 10 mg IV as a single dose.
How supplied
Basiliximab
powder for injection
- 10mg
- 20mg
