Amoxicillin

DEA Class; Rx

Common Brand Names; Amoxil, Moxatag (DSC), Trimox

Indicated for the treatment of Ear, Nose, & Throat Infections

Indicated for the treatment of Genitourinary Tract Infections

Indicated for the treatment of Skin & Skin Structure Infections

Indicated for the treatment of Lower Respiratory Tract Infections

Indicated for the treatment of Helicobacter Pylori

Indicated for the treatment of Anthrax

Indicated for the treatment of Infective Endocarditis

Indicated for the treatment of Lyme Disease (Off-label), Chlamydial Infection in Pregnant Women (Off-label)

Documented hypersensitivity to penicillins, cephalosporins, imipenem

• Anaphylaxis
• Anemia
• AST/ALT elevation
• Mucocutaneous candidiasis
• Diarrhea
• Headache
• Nausea
• Vomiting
• Rash
• Pseudomembranous colitis
• Serum sickness-like reactions
• Mucocutaneous candidiasis
• Gastrointestinal (eg, black hairy tongue and hemorrhagic/pseudomembranous colitis, which may occur during or after treatment)

Anaphylaxis has been reported rarely but is more likely to occur following parenteral therapy with penicillins

Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents; severity may range from mild diarrhea to fatal colitis; CDAD may occur over 2 months after discontinuation of therapy; if CDAD is suspected or confirmed, discontinue immediately and begin appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation

Do not administer in patients with infectious mononucleosis because of risk of development of erythematous skin rash

Do not administer to patients in the absence of a proven or suspected bacterial infection because of risk of development of drug-resistant bacteria

Superinfections with bacterial or fungal pathogens may occur during therapy; if suspected, discontinue immediately and begin appropriate treatment

Chewable tablets contain aspartame, which contains phenylalanine

Use caution in patients with allergy to cephalosporins, carbapenems

Endocarditis prophylaxis: use for only high-risk patients, as per recent AHA guidelines

High doses may cause false urine glucose test by some methods

May cause severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP); if patients develop a skin rash they should be monitored closely and therapy discontinued if lesions progress

Available data from published epidemiologic studies and pharmacovigilance case reports over several decades with amoxicillin use have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes

Data from a published clinical lactation study reports that amoxicillin is present in human milk; published adverse effects with amoxicillin exposure in breastfed infant include diarrhea