Classes
DEA Class; Rx
Common Brand Names; Miochol E
- Miotics, Direct-Acting
Description
Direct-acting parasympathomimetic ophthalmic agent; naturally-occurring neurohormone that mediates nerve impulse transmission at cholinergic sites.
Used intraocularly to produce rapid miosis during ophthalmic surgery.
Indications
Indicated for miosis induction in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment ocular surgery where rapid miosis may be required.
Adverse Effects
- Corneal edema
- Corneal clouding
- Corneal decompensation
- Bradycardia
- Flushing
- Hypotension
- Breathing difficulty
- Sweating
Warnings
Use reconstituted solution immediately; aqueous solution unstable
Instill gently; forceful jet may rupture the hyaloid, cause vitreous loss, or traumatize/perforate iris
Systemic effects (rare) can cause problems for patients with asthma, acute heart failure, GI spasm, peptic ulcer disease, urinary tract obstruction, acute heart failure, and hyperthyroidism
Pregnancy and Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use with caution
Maximum Dosage
20 mg (2 mL of 1% Miochol-E solution) intraocularly per eye is usually sufficient. A second application may be needed for prolonged miosis.
20 mg (2 mL of 1% Miochol-E solution) intraocularly per eye is usually sufficient. A second application may be needed for prolonged miosis.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Acetylcholine chloride
powder for injection
- 20mg
