Acebutolol

DEA Class;  Rx

Common Brand Names; Sectral

• Fatigue (11%)
• Dizziness (6%)
• Headache (6%)
• Constipation (4%)
• Diarrhea (4%)
• Dyspnea (4%)
• Dyspepsia (4%)
• Nausea (4%)
• Flatulence (3%)
• Insomnia (3%)
• Abdominal pain (2%)
• Bradycardia (2%)
• Chest pain (2%)
• Dysuria (2%)
• Edema (2%)
• Heart failure (2%)
• Hypotension (2%)
• Impotence (2%)
• Myalgia (2%)
• Pharyngitis (2%)
• Pruritus (2%)
• Rhinitis (2%)
• Vomiting (2%)
• Wheezing (2%)

Use with caution in patients with myasthenia gravis

Exacerbation or induction of psoriasis reported with therapy; cause and effect not established

Use caution and monitor for progression of arterial obstruction in patients with peripheral vascular disease and Raynaud disease; therapy may precipitate or aggravate symptoms of arterial insufficiency

Prior to use a β-blocker, adequate alph1-receptor blockade required in patients with pheochromocytoma

While taking β-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic; such patients may be unresponsive to usual doses of epinephrine used to treat allergic reaction

Sympathetic stimulation may be essential for support of circulation in individuals with diminished myocardial contractility; inhibition by β-adrenergic receptor blockade may precipitate more severe failure; although β-blockers should be avoided in overt cardiac failure, acebutolol can be used with caution in patients with a history of heart failure who are controlled with digitalis and/or diuretics; both digitalis and acebutolol impair AV conduction; if cardiac failure persists, therapy should be withdrawn

Pregnancy Category: B; D in 2nd and 3rd trimesters (expert analysis). Neonates of mothers who have received acebutolol during pregnancy have reduced birth weight, decreased blood pressure, and decreased heart rate.

Lactation: excreted into milk/not recommended

Acebutolol