Classes
DEA Class; Rx
Common Brand Names; Trilisate ASA combination
- NSAIDs
Description
Inhibits cyclooxygenase; [at least 2 isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2)], thereby inhibiting prostaglandin synthesis
Indications
Indicated for Osteoarthritis, Rheumatoid Arthritis, Fever, Shoulder pain
Contraindications
Absolute: bleeding disorders, chronic advanced renal insufficiency, GI hemorrhage, hemorrhagic diathesis, salicylate allergy
Relative: Erosive gastritis, GI ulcer, NOS
Adverse Effects
GI pain/ulceration/bleeding
Tinnitus, hearing loss
Hepatotoxicity
Renal damage
Premature hemolysis
CNS alteration
Pulmonary edema (salicylate-induced/noncardiogenic)
Dermatologic problems, urticaria
Angioedema
Bronchospasm
Warnings
Anemia, gout, hepatic function impairment, hypertension, hypoprothrombinemia, nasal polyps, renal function impairment, thyrotoxicosis, vitamin K deficiency
Use of salicylates in pediatric pts with varicella or influenza-like illness is associated with incr incidence of Reye’s Syndrome
Pregnancy and Lactation
Pregnancy Category: C; D if used for prolonged periods or near term
Lactation: excreted in human breast milk; adverse effect on the nursing infant
Maximum Dosage
Osteoarthritis
1000-3000 mg PO q8-12hr
Rheumatoid Arthritis
1000-3000 mg PO q8-12hr
Fever
1000-1500 mg PO q12hr
Renal Impairment
Avoid use in severe renal impairment
Other Indications & Uses
Shoulder pain
Pediatric
Mild to Moderate Pain
<37 kg: 50 mg/kg PO divided q12hr
>37 kg: 2250 mg PO divided q12hr
Fever
<37 kg: 50 mg/kg PO divided q12hr
>37 kg: 2250 mg PO divided q12hr
How supplied
Choline magnesium trisalicylate
liquid
- 500mg/5mL (294 mg choline salicylate, 362 mg magnesium salicylate)
tablet
- 500mg (294 mg choline salicylate, 362 mg magnesium salicylate)
- 750mg (440 mg choline salicylate, 544 mg magnesium salicylate)
- 1000mg (587 mg choline salicylate, 725 mg magnesium salicylate)
