Classes
DEA Class; Rx
Common Brand Names; BuSpar, Buspirex, Bustab, LinBuspirone
- Antianxiety Agents;
- Anxiolytics, Nonbenzodiazepines
Description
Oral anxiolytic pharmacologically distinct from other anxiolytics
Used for adults with generalized anxiety disorder; efficacy in pediatric patients is uncertain
Not effective for the acute relief of anxiety due to a delayed onset of effect
Indications
Indicated for the treatment of generalized anxiety disorder (GAD) or for the short-term relief of the symptoms of anxiety.
Contraindications
Hypersensitivity
Adverse Effects
- Dizziness (12%)
- Drowsiness (10%)
- Nausea (8%)
- Headache (6%)
- Nervousness (5%)
- Blurred vision (2%)
- Confusion (2%)
- Diarrhea (2%)
- Excitement (2%)
- Insomnia (2%)
- Myalgia (1%)
- Numbness (2%)
- Paresthesia (1%)
- Rash (1%)
- Tremor (1%)
- Weakness (2%)
- Nasal congestion (1%)
- Sore throat (1%)
- Nonspecific chest pain (1%)
- Tinnitus (1%)
- Dream disturbances (1%)
- Akathisia
- Allergic reaction
- Anorexia
- Bruising
- Galactorrhea
- Heart failure
- Menstrual irregularity
- Suicidal ideation
- Syncope
- Alopecia
- Eosinophilia
- Edema
- Enuresis
- Increased ocular pressure
- Visual disturbances
- Rectal bleeding
- Photophobia
- Dystonia
Warnings
Do not use PRN for anxiety
Will not prevent withdrawal from other anxiolytics, such as benzodiazepine
May cause cognitive motor impairment
Restlessness syndrome associated with therapy
Use in severe renal/hepatic impairment not recommended
Use with MAO inhibitors may result in hypertensive reaction (use not recommended)
Pregnancy and Lactation
Pregnancy category: B
Lactation: Excretion in milk unknown/not recommended
Maximum Dosage
5 mg IV total cumulative dose for suspected benzodiazepine overdose. If patient unresponsive at this dose, cause of sedation not likely to be benzodiazepine. Max dose for reversal of conscious sedation is 1 mg IV.
5 mg IV total cumulative dose for suspected benzodiazepine overdose. If patient unresponsive at this dose, cause of sedation not likely to be benzodiazepine. Max dose for reversal of conscious sedation is 1 mg IV.
Single doses of 10 mcg/kg IV (Max: 200 mcg/dose); doses may be repeated as necessary up to a total cumulative dose of 50 mcg/kg IV (Max: 1 mg). Alternatively, 10 mcg/kg/hour via continuous IV infusion has been used off-label.
Single doses of 10 mcg/kg IV (Max: 200 mcg/dose); doses may be repeated as necessary up to a total cumulative dose of 50 mcg/kg IV (Max: 1 mg). Alternatively, 10 mcg/kg/hour via continuous IV infusion has been used off-label.
Safety and efficacy have not been established. However, single doses of 30 mcg/kg IV (Max: 200 mcg/dose) have been used off-label; doses may be repeated as necessary up to a total cumulative dose of 50 mcg/kg IV (Max: 1 mg). Alternatively, 10 mcg/kg/hour via continuous IV infusion has been used off-label.
Safety and efficacy have not been established. However, single doses of 20 mcg/kg IV have been used off-label; doses may be repeated as necessary up to a total cumulative dose of 50 mcg/kg IV. Alternatively, 20 mcg/kg/hour via continuous IV infusion has been used off-label.
How supplied
Buspirone
tablet
- 5mg
- 7.5mg
- 10mg
- 15mg
- 30mg
