Classes
DEA Class; OTC
Common Brand Names; Neo DM Suspension, Dimaphen DM, Children’s Dimetapp Cold & Cough
- Cough/Cold, Non-narcotic Combos;
- Antihistamine/Antitussive/Decongestant Combos
Description
Oral sedating antihistamine and non-opioid antitussive combination
Used to relieve symptoms associated with the common cold or allergies including rhinorrhea, sneezing, and cough in adults and pediatric patients 6 years and older
These products may be abused due to dextromethorphan content and are known by the slang term “Triple C”
Indications
Indicated for the Relief of Cold Symptoms
Contraindications
- Hypersensitivity
- Newborn infants, premature infants
- Nursing mothers
- Severe hypertension
- Severe coronary artery disease or ischemic heart disease
- Use within 14 days of MAO inhibitor
- Narrow-angle glaucoma
- Urinary retention
- Peptic ulcer
- During asthma attack
- Treatment of lower respiratory tract conditions, including asthma
Adverse Effects
- Dizziness
- Drowsiness
- Dry mouth, throat, and nose
- Thickening of mucus in nose or throat GI disturbances
- Reflex tachycardia
- Excitability
- Restlessness
- Headache
- Hypertension
- Severe peripheral and visceral vasoconstriction
Warnings
Do not use the medicine to make a child sleepy; misuse of this medicine may cause death in very young children
See healthcare professional if symptoms do not improve after 7 days, or experiencing fever, rash, or headaches
If surgery or medical tests need to be performed, tell doctor ahead of time if medicine taken within past few days
Avoid becoming overheated or dehydrated during exercise and hot weather; this medicine can decrease sweating and you may be more prone to heat stroke
Patients with persistent cough, such as occurs with smoking, asthma, emphysema, or where cough is accompanied by excessive secretions should not take this product; persistent cough may be sign of serious condition
If cough persists for more than 1 week, tends to recur, or is accompanied by fever, rash, or persistent headache, consult a doctor
Use caution when giving to children or patients with chronic pulmonary disease, shortness of breath, difficulty in breathing, asthma, emphysema, high blood pressure, heart disease, diabetes, thyroid disease, or difficulty in urination due to enlargement of the prostate gland unless directed by a physician
Antihistamines may impair mental and physical abilities required for performance of potentially hazardous tasks, such as driving a car or operating machinery and may impair mental alertness in children
At doses higher than recommended dose, nervousness, dizziness, or sleeplessness may occur; especially in infants and small children, antihistamines in overdosage may cause hallucinations, convulsions, and death
If nervousness, dizziness, or sleeplessness occurs, discontinue use and consult healthcare professional
Administration of dextromethorphan hydrobromide may be accompanied by histamine release and should be used with caution in atopic children
If hypertensive crisis occurs, these drugs should be discontinued immediately and therapy to lower blood pressure instituted immediately; fever should be managed by means of external cooling
Pregnancy and Lactation
Animal reproduction studies not conducted; also not known whether drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; medication should be given to a pregnant woman only if clearly needed
Because of higher risk of intolerance of antihistamines in small infants generally, and in newborns and prematures in particular, this medication is contraindicated in nursing mothers
Maximum Dosage
Do not exceed recommended dosage limits for the specific product prescribed; the following are general guidelines:
Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
12 years: Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
6 to 11 years: Chlorpheniramine 12 mg/day PO; dextromethorphan 60 mg/day PO.
Less than 6 years: Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Brompheniramine maleate/dextromethorphan hydrobromide/phenylephrine hydrochloride
Brompheniramine/dextromethorphan/phenylephrine
oral solution
- (1mg/5mg/2.5mg)/5mL
