Classes
DEA Class; Rx
Common Brand Names; Tenoretic
- Thiazide Combos
Description
Oral beta-blocker and long-acting thiazide diuretic; additive hypotensive activity; used qd for HTN; long-acting; beta-1-specific; hydrophilic, renally eliminated; lacks membrane-stabilizing activity (MSA) or intrinsic sympathomimetic properties (ISA).
Indications
Indicated for the treatment of hypertension in patients who do not respond to monotherapy.
NOTE: Individualize the dosage by titration of the separate components. If the optimal dose corresponds to the ratio contained in the combination formulation, this product can be used for convenient dosing.
Contraindications
Anuria
Cardiogenic shock
Heart block 2°/3°
Hypersensitivity to either component or sulfonamides
Overt cardiac failure
Sinus bradycardia
Untreated pheochromocytoma
Adverse Effects
No adverse effects specific to the combination have been observed; adverse effects limited to those previously reported with atenolol and chlorthalidone
Atenolol
- 2/3° AV block
- Bradycardia
- Cold extremities
- Diarrhea
- Drowsiness
- Hypotension
- Leg pain
- Lethargy
- Lightheadedness
- Nausea
- Postural hypotension
- Unusual dreams
- Vertigo
Chlorthalidone
- Blurred vision, xanthopsia
- Constipation
- Diarrhea
- Dizziness
- Electrolyte abnormalities
- Headache, vasculitis
- Hyperglycemia
- Hyperuricemia
- Hypotension
- Impotence
- Loss of appetite
- Muscular spasticity, restlessness
- Nausea/vomiting
- Paresthesia
- Photosensitivity, phototoxicity
Warnings
Surgery/Anesthesia: Chronically administered beta-blockers should not be routinely withdrawn prior to major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures
Bronchospastic disease
Cerebrovascular insufficiency
Correct hypokalemia before initiating therapy
CHF, beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe failure
Use caution in diabetes mellitus, fluid or electrolyte imbalance (hypochloremic alkalosis, hypercalcemia, hyponatremia), moderate or high cholesterol concentrations, history of asthma, hyperuricemia or gout, hypotension, SLE
Hyperthyroidism/thyrotoxicosis, liver disease
May aggravate digitalis toxicity
Peripheral vascular disease
Renal impairment
Risk of male sexual dysfunction
Sensitivity reactions may occur with or without history of allergy or asthma
Compromised left ventricular function
Patients receiving clonidine – discontinue atenolol several days prior to withdrawal of clonidine
Pregnancy and Lactation
Pregnancy Category: D
Lactation: excreted in breast milk, use caution
Maximum Dosage
100 mg/day PO atenolol and 25 mg/day PO chlorthalidone.
100 mg/day PO atenolol and 25 mg/day PO chlorthalidone.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
Safety and efficacy have not been established.
How supplied
Atenolol/Chlorthalidone
tablet
- 50mg/25mg
- 100mg/25mg
